Perstorp

New study clears 2-EHA of suspicion of additional classification by ECHA

  • A recent study with 2-ethylhexanoic acid (2-EHA) did not indicate any adverse effects regarding reproduction at the highest dose tested.
  • As a result ECHA has finalized the Community Rolling Action Plan (CoRAP) evaluation; 2-EHA is no longer under consideration for additional classification. The product is considered safe with risk mitigation measures in place.

Perstorp April 5, 2018 - Recently 2-ethylhexanoic acid (2-EHA) has shown no adverse effects regarding reproduction at the highest dose tested in a study executed at the request of the European Chemicals Agency (ECHA). Because of earlier suspicions on reproductive toxicity, ECHA had 2-EHA listed in the Community Rolling Action Plan (CoRAP) as CMR (reproductive toxicity - fertility) and potential neurodevelopmental toxicity. This listing has now been removed: 2-EHA is no longer under consideration for additional classification and labeling. The product is considered safe with risk mitigation measures in place.

The reason for this listing was the suspected toxicity on fertility as well as wide dispersive use, potential consumer use and high aggregated tonnage level. These concerns were based on the results of non-guideline and non-GLP studies. To be able to assess the potential hazard of 2-ethylhexanoic acid, an additional reproductive toxicity study was performed on rats. The outcome of this study did not indicate any adverse effects regarding reproduction at the highest dose tested.

Based on the available information, the evaluating Member State Spain supported the conclusion. Spain also concluded in their report that no additional classification is required and that there is no need of further risk management measures based on the exposure scenarios assessed in the dossier. 2-EHA will remain classified as Reproductive Toxicity Category 2, meaning consumer use should be restricted and some risk mitigating measures need to be taken into account when used at production facilities.

Product manager for Perstorp (the world’s largest producer of 2-EHA), Andreas Nilsson states: “Despite 2-EHA being the most accessible and cost-effective carboxylic acid available, the suspicion caused the market sentiment to sway towards replacement of 2-EHA in some cases. These studies now make 2-EHA the best-investigated carboxylic acid. We are very happy that these suspicions have been lifted.“

2-EHA (2-ethylhexanoic acid) is widely used in esters for PVB film plasticizers and synthetic lubricants, in production of metal soaps for paint driers, in automotive coolants and PVC stabilizers. Other application areas include wood preservatives, catalyst for polyurethane and in pharmaceuticals. Yearly production amounts to almost 300.000 tons.

For more information on 2-EHA, visit www.perstorp.com.
For more information on the substance evaluation of 2-EHA, click here>>

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Perstorp Holding AB
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Notes for editors

A global leader in high growth niches

The Perstorp Group, a trusted world industrial leader, places focused and market-driven innovation at your fingertips. Our culture of performance builds on 130 years of experience and represents a complete chain of solutions in organic chemistry, process technology and application development. As the global leader in high growth niches, such as powder and UV cured coatings, plasticizers, synthetic lubricants and grain preservation, we are committed to develop products providing essential properties to enhance the quality, performance and profitability of our customers’ products and processes. As we look to the future, we strive for the development of smarter and safer products and sustainable processes that reduce environmental impact and create real value in end-products. Perstorp has approximately 1,600 employees and manufacturing units in Asia, Europe and North America. Sales in 2016 amounted to more than SEK 11,3 billion. Discover your winning formula at www.perstorp.com.

Related images

2-EHA is frequently used in paint dryers.
(Photo: Shutterstock)

 

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Tony Toebak
Perstorp

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EMG

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